Our Team

Steven Lotz – Director

Taylor Bertucci PhD – Research Scientist

Sue Borden – Research Technician

Katherine Stevens – Research Technician

Amelia Rossi – Research Technician

Dylan Murphy – Research Technician

Catherine Hamann PhD – Post-Doctoral Fellow

Additional Scientific Team

NeuraCell is backed by a team of scientists at Neural Stem Cell Institute, a not-for-profit organization, led by the Scientific Director, Dr. Sally Temple, an expert in the field of stem cell research and recipient of numerous recognition awards in the field.

Publications

  1. Bertucci T, Bowles KR, Lotz S, Qi L, Stevens K, Goderie SK, Borden S, Oja LM, Lane K, Lotz R, Lotz H, Chowdhury R, Joy S, Arduini BL, Butler DC, Miller M, Baron H, Sandhof CA, Silva MC, Haggarty SJ, Karch CM, Geschwind DH, Goate AM, Temple S. Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with MAPT Mutations. bioRxiv. 2023 Jul 11;. doi: 10.1101/2023.07.11.548571. PubMed PMID: 37503195; PubMed Central PMCID: PMC10369860.
  2. Shiravi S, Yufa A, Papavasileiou P, Lotz S, Murphy D, Bertucci T, Temple S, Finan JD. A Model of Traumatic Brain Injury Oligomerizes Tau in Cortical Organoids and Induces Clinically Relevant Pathologies that Synergize with MAPT Mutation. J Neurotrauma. 2025 Sep 6;. doi: 10.1177/08977151251374286. [Epub ahead of print] PubMed PMID: 40900146.
  3. Joly J, Budamagunta V, Zhang Z, Nortman B, Jouzi M, Bhatnagar R, Egertson JD, Flaster ME, Grothe R, Guha S, Kaneshige K, McVey K, Nelson N, Perera RT, Tan SJ, Trinh T, Arnott D, Lipka J, Pandya NJ, Rougé L, Wendorff TJ, Kirkpatrick DS, Rohou A, Butler DC, Lotz S, Forton A, Sartori ER, Schwarz JE, Brereton PS, Chen K, Darcy MA, Golnabi HR, Hartley R, Indermuhl PF, Inman CE, Jin KM, Katsyuk S, Kota R, Lowry B, Menger JC, Miller DA, Newman MR, Ogunyemi A, Robinson JK, Steiner N, Sun J, Tabakman S, Wang L, Wang Z, Wilcox SK, Kapp GT, Patel S, Temple S, Bertucci T, Blanchard J, Huhmer A, Sankar S, Juneau K, Mallick P. Large-scale single-molecule analysis of tau proteoforms. bioRxiv. 2025 Jul 21;. doi: 10.1101/2025.06.26.660445. PubMed PMID: 40667364; PubMed Central PMCID: PMC12262352.
  4. Silva MC, Lindmeier H, Pigini P, Laughlin J, Yu Y, Morrill C, Arnold MA, Barraza SJ, Saadipour K, Dieterich M, Minnella A, Datta K, Zhang N, Narasimhan J, Trotta CR, Woll MG, Welch EM, Benzow K, Karanjeet K, Lotz S, Bertucci T, Temple S, Haggarty SJ, Koob M, Trimmer J, Weetall M, Morini E. MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies. bioRxiv [Preprint]. 2025 May 10:2025.05.06.652428. doi: 10.1101/2025.05.06.652428. PMID: 40655000; PMCID: PMC12247953.
  5. D’Brant L, Rugenstein N, Na SK, Miller MJ, Czajka TF, Trudeau N, Fitz E, Tomaszek L, Fisher ES, Mash E, Joy S, Lotz S, Borden S, Stevens K, Goderie SK, Wang Y, Bertucci T, Karch CM, Temple S, Butler DC. Fully Human Bifunctional Intrabodies Achieve Graded Reduction of Intracellular Tau and Rescue Survival of MAPT Mutation iPSC-derived Neurons. bioRxiv. 2024 Jun 1;. doi: 10.1101/2024.05.28.596248. PubMed PMID: 38854137; PubMed Central PMCID: PMC11160687.
  6. Pesantez Torres F, Tokranova N, Amodeo E, Bertucci T, Kiehl TR, Xie Y, Cady NC, Sharfstein ST. Interfacing neural cells with typical microelectronics materials for future manufacturing. Biosens Bioelectron. 2023 Dec 15;242:115749. doi: 10.1016/j.bios.2023.115749. Epub 2023 Oct 13. PubMed PMID: 37839350.
  7. Glasauer SMK, Goderie SK, Rauch JN, Guzman E, Audouard M, Bertucci T, Joy S, Rommelfanger E, Luna G, Keane-Rivera E, Lotz S, Borden S, Armando AM, Quehenberger O, Temple S, Kosik KS. Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol. Stem Cell Reports. 2022 Sep 13;17(9):2127-2140. doi: 10.1016/j.stemcr.2022.07.011. Epub 2022 Aug 18. PubMed PMID: 35985329; PubMed Central PMCID: PMC9481908.
  8. Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. 2021 Aug 19;184(17):4547-4563.e17. doi: 10.1016/j.cell.2021.07.003. Epub 2021 Jul 26. PubMed PMID: 34314701; PubMed Central PMCID: PMC8635409.
  9. Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, Temple S, Goate A, Brennand KJ, Phatnani H. Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells. 2020 Jun 5;9(6):1406. doi: 10.3390/cells9061406. PMID: 32516938; PMCID: PMC7349756.
  10. Fisher ES, Amarante MA, Lowry N, Lotz S, Farjood F, Temple S, Hill CE, Kiehl TR. Single cell profiling of CD45+ spinal cord cells reveals microglial and B cell heterogeneity and crosstalk following spinal cord injury. J Neuroinflammation. 2022 Nov 4;19(1):266. doi: 10.1186/s12974-022-02627-3. PMID: 36333772; PMCID: PMC9635187.
  11. Lotz S, Goderie S, Tokas N, Hirsch SE, Ahmad F, Corneo B, Le S, Banerjee A, Kane RS, Stern JH, Temple S, Fasano CA. Sustained levels of FGF2 maintain undifferentiated stem cell cultures with biweekly feeding. PLoS One. 2013;8(2):e56289. doi: 10.1371/journal.pone.0056289. Epub 2013 Feb 20. PMID: 23437109; PMCID: PMC3577833.